Finding Transcriptional Enhancer Sequences Active During the Establishment of Left-Right Asymmetry in the Vertebrate Embryo

Seminar Date: 
Seminar Time: 
11am - 12pm
Seminar Location: 
5607 Baum Boulevard, Room 407A
Dennis Kostka, PhD
Presenter's Institution: 
Department of Developmental Biology


Vertebrates show evolutionarily conserved left-right biases in placement and morphology of their visceral organs, but specification of the left-right body axis remains one of the least understood processes in the developing embryo. Transcriptional enhancer sequences are gene regulatory elements that play important roles in implementing precise gene expression patterns necessary during development. Current estimates of the number of enhancer sequences are on the order of a million; leveraging public in-house data we present a computational approach to highlight a high-confidence subset of enhancer sequences active at the time when transcriptional asymmetries between the left and right sides arise.